Ever heard of a shark‑derived compound that can slow down blood vessel growth? That’s squalamine, an aminosterol first isolated from shark liver oil. Researchers love it because it blocks the formation of new blood vessels (anti‑angiogenic) and can fight infections. In plain language, squalamine may help shrink tumors, calm eye disease, and even tackle acne‑like skin issues.
Doctors and scientists have tested squalamine for a handful of conditions. The biggest buzz is around cancer – early trials showed the drug can starve tumors by cutting off their blood supply. It’s also been explored for macular degeneration, where abnormal vessels damage the retina. Outside of the clinic, some skin‑care brands add squalamine to creams, claiming it reduces redness and keeps pores clear. While the evidence is still growing, these uses illustrate where the compound shines.
Right now, squalamine isn’t an over‑the‑counter product in most places. It’s usually given as an eye‑drop solution or a short injectable course in clinical studies. Doses vary: eye drops often contain 0.03% squalamine applied twice daily, while injection studies used 1–2 mg per kilogram of body weight over a few weeks. Because the drug is still under investigation, you should only use it under a doctor’s supervision.
Side effects are generally mild but worth watching. Some people report temporary eye irritation, a slight headache, or mild nausea after an injection. Serious reactions are rare, but allergic responses can happen, so stop use and call a health professional if you notice swelling or difficulty breathing.
Pregnant or nursing moms should avoid squalamine until more data is available. Also, if you’re on blood‑thinners or anti‑inflammatory meds, discuss possible interactions with your clinician – the anti‑angiogenic action could theoretically affect clotting.
When looking for a source, steer clear of shady online pharmacies that claim to sell “squalamine capsules” without a prescription. Legitimate options come from licensed clinics or research programs. Always verify the pharmacy’s credentials, check for a valid pharmacy license, and never share personal or payment info on unsecure sites.
Bottom line: squalamine is a promising, shark‑based molecule that targets blood‑vessel growth and microbes. It’s most useful in controlled medical settings for eye disease and some cancer research. If you’re curious about trying it, the safest route is a physician‑guided prescription or enrollment in a clinical trial.
Keep an eye on upcoming studies – 2025 is expected to bring new trial results that could expand squalamine’s approved uses. Until then, treat any product claiming quick fixes with healthy skepticism and always prioritize professional medical advice.
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